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This leads to a metabolic braking phenomenon that prevents energy waste ( 3 Physiological mechanisms underlying the imbalance of glycolipid metabolism in RA 3.1 Metabolic reprogramming and regulatory imbalance in RA immune cells Activated T cells in RA are supported by GLUT1/PFK-1 upregulation and the pentose phosphate pathway (PPP) for proliferation and inflammatory activity ( This metabolic dysregulation is driven by an aberrant mTOR-HIF-1-AMPK signaling axis