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Treatment with GLP-1 receptor agonists, such as liraglutide and semaglutide, can induce satiation in the central nervous system, achieve significant long-term weight loss and improve insulin sensitivity [13]

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The overall community consensus on r/Ozempic and r/WeightLoss at the six-week mark is surprisingly consistent: most people lost between 6 and 10 lbs, most experienced the week 4 plateau, almost everyone noticed appetite reduction before the scale moved, and the side effects (nausea, fatigue) were worst in weeks 13 before becoming manageable

In a meta-analysis of 1,119 participants with type 2 diabetes treated with GLP-1 receptor agonists across three cohorts, carriers of the more severe PAM variant saw their average blood sugar marker, HbA1c, drop by just 0.69 percentage points after six months, compared with 1.24 points in non-carriers