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doi: 10.1007/s10753-014-9957-3

MECHANISM OF ACTION: KPV KPV exerts its anti-inflammatory effects through intracellular pathways, independent of melanocortin receptors (MC-Rs)

In contrast, the detrimental effect of mitophagy mostly occurs in scenarios of excessive activation or abnormal regulation: when cells encounter sustained and severe pathological stress (such as severe ischemia and severe inflammation), mitophagy is abnormally activated, which excessively degrades functionally normal mitochondria, leading to disorders of cellular energy metabolism, insufficient ATP synthesis, and simultaneous disruption of the normal proliferation and renewal balance of mitochondria in cells

To resemble a peptide that exists naturally within our gut