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Enzymatic abnormality in erythrocytes of a population sensitive to Vicia faba or hemolytic anemia induced by drugs

We obtained a total of 60,687,163 reads for 16S rRNA gene sequencing (mean of 124,063 reads per sample in toddlers, 122,020 reads per sample in adolescents and 117,555 reads per sample in adults) and a total of 216,779,268 reads for shotgun metagenomics (mean of 485,157 reads per sample in toddlers, 411,977 reads per sample in adolescents and 425,492 reads per sample in adults) (Supplementary Tables S2B-S3)

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This catalytic reaction of GPX4 follows a tert-uni ping pong mechanism, involving redox reactions of the selenocysteine (Yang et al., 2014)