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Heme oxygenase 1 (HO-1) is an NRF2 target gene that prevents FH deficiency-mediated succinate stagnation through the heme synthesis and degradation pathway ( BEYOND REGULATING REDOX HOMEOSTASIS: NRF2 PROMOTES ANABOLIC PATHWAYS IN CANCERS In addition to coordinately activating the genes encoding detoxifying enzymes and antioxidant proteins, the constitutive accumulation of Nrf2 confers chemo- and radio-resistance for cancer cell survival

Several peptides of research interest, including some anabolic compounds, sit in or near this schedule

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The 76-year-old from Toronto also has diabetes and was prescribed Ozempic in 2023 to bring down her weight and improve blood sugar control