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Digestive discomfort including bloating or mild cramping has been reported, though these effects are generally transient and resolve within hours

Note that in a larger set of 77 human coronaviruses, a serine (S) in P4 is very common (12), and in addition the sequence SI in the TXNRD1 site is isosteric to TV, the aligned residues in the nsp12/13 site, because transfer of a methyl group from threonine to valine would result in serine and isoleucine

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doi: 10.1073/pnas.0510033103