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It seems that metabolic stress during obesity and metabolic syndrome induces a compensatory response, being characterized by increased Zn-mediated mechanisms of antioxidant protection
Given the prior evidence for lower GSH levels in patients with MDD, our hypothesis is that glutathione levels may be lower in patients compared to healthy controls and that these differences may be brain-region specific
But weight displayed on the scale is only part of the story
Our results not only reveal early metabolomic problems in the motor cortex, but also suggest that maintaining NAD + balance could offer a therapeutic treatment strategy for diseased UMNs with TDP-43 pathology
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