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Weight loss was also assessed in the SCALE Sleep Apnea RCT, in which 359 non-diabetic individuals (mean age 48.5 years, mean BMI 39.1 kg/m 2 ), mostly males with untreated obstructive sleep apnea (OSA), were enrolled to investigate the effect of liraglutide on disease severity 20

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Changes in taste: Some people notice a change in how food or drink tastes, which may affect appetite or food preferences

Similar content being viewed by others 1 Introduction Significant challenges in obtaining sufficient systemic exposure of orally administered peptide- and protein-based drugs are due to the acidic environment and presence of proteolytic enzymes in the stomach, and the limited permeability of peptides and proteins through the gastrointestinal epithelium [1, 2]