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Supporting may be a dramatic decrease of glutathione levels in the rat brain after a paracetamol oral overdose (3.0 g/kg) (4) and brain tissue susceptibility to oxidative stress (high content of peroxidizable unsaturated fatty acids, high oxygen consumption per unit weight, but poorly developed antioxidative defense mechanisms) (5)

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Treatment of MAT deficiency includes supplementation with betaine, folic acid, vitamin B6, and vitamin B12, and a methionine-restricted diet.14 Folate, Vitamin B6, and Vitamin B12 Deficiencies Adequate levels of folate, vitamin B6, and vitamin B12 are needed to properly metabolize homocysteine