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OLK is one common type of OPMDs whose overall malignant transformation rate is estimated to be 3.5% (Singh et al., 2004)

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Therefore, it is important to better understand the pathophysiology of CD based on molecular aspects of OxS, because new antioxidant compounds like drugs, hormones, functional foods, probiotics, natural active compounds from vegetal sources could become promising therapeutic modalities of the disease (17-20)