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Clinical trials, including the STEP programme, demonstrated that participants using Wegovy alongside lifestyle interventions achieved an average weight loss of 1215% of their initial body weight over 68 weeks in non-diabetic populations, with somewhat lower average losses in people with type 2 diabetes

If we want berberine to compete with something like Ozempic, researchers need to find a way to increase the dose , increase the potency/bioavailability , and reduce those side effects

doi: 10.1124/jpet.103.051987 89 DeYoungMBMacConellLSarinVTrautmannMHerbertP

Thyroid concerns exist because GLP-1 receptor agonists may increase thyroid C-cell tumors in animal studies, though human data remains limited