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As briefly mentioned before, repeated injections in the same spot can lead to tissue damage, irritation, lipohypertrophy, a condition where fatty lumps form under the skin, or lipoatrophy, a condition that causes fat loss resulting in dents under the skin

Overview of epidemiology and contribution of obesity and body fat distribution to cardiovascular disease: An update

The combination addresses what I consider the biggest weakness of GLP-1 therapy alone: the risk of becoming skinny fat where you lose weight but end up with a higher body fat percentage because so much muscle was lost along the way