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These GLP-1 (glucagon-like peptide-1) agonists are prescribed medications used to treat type 2 diabetes

doi: 10.3389/fnins.2021.584649 Received 17 July 2020 Accepted 04 March 2021 Published 11 May 2021 Volume 15 - 2021 Edited by Marco Solmi, University of Padua, Italy Reviewed by Kenji Hashimoto, Chiba University, Japan

Although much of this evidence derives from animal models, making direct extrapolation to humans complex, significant functional commonalities exist between the murine and human BBB, including glucose transport, the presence of circumventricular organs (CVOs), and saturable transport systems [33]

This is often referred to as the "GLP-1 trap": employees lose weight quickly, but the underlying behaviors don't change so as soon as the medication stops, the weight comes back