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59:772-783 [PMC free article: PMC5928430] [PubMed: 29487091] 50

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Dopamine receptor 3 might be an essential molecule in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

Hypoxia has been posited as a possible link between vascular dysfunction and calciphylaxis in MS (179), where vascular dysfunction with defective angiogenesis leads to recurrent episodes of ischemia-reperfusion injury, increasing the products of oxidative stress, which results in tissue hypoxia (180)