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Redistribution of compressive stresses causes regions of low and high compressive stresses, both of which are known to inhibit disc cell metabolism 47 and thereby increase the risk of internal disruption and degeneration

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Second, although the conjugation of the toxic intermediate NAPQI by glutathione is an important protective mechanism, it occurs after the production of NAPQI, while glucoronidation removes APAP before the production of NAPQI

-ketoglutarate enzyme activity significantly increased when we blocked pyruvate with UK5099 in IAV infected DC (S2F Fig)