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According to the study, UA had a direct proinflammatory effect on human macrophages manifested by increased macrophage phagocytic activity, the production of TNF-alpha and toll-like receptor 4 (TLR4), and downregulated the urate anion transporter 1 expression. [ Uric acid is believed to contribute to the antioxidant potential in plasma but within the cell it is rather pro-oxidant

Image with caption: "TRULICITY, the first once-weekly GLP-1 RA in a ready-to-use pen indicated for adult patients with type 2 diabetes is now available in Canada (CNW Group/Eli Lilly Canada Inc.)"

GPF received honoraria for speaker activities, for serving on advisory boards, or consultancy from AstraZeneca, Boehringer Ingelheim, Eli Lilly, Guidotti, Novartis, Novo Nordisk, and Sanofi