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Improvements in Maritime Technology and International Trade The Columbian Exchange was made possible by improvements in maritime technology, such as the development of the caravel ship and the invention of the magnetic compass

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Opioid poisoning, cirrhosis and external mortality We defined opioid deaths using the US Centers for Disease Control and Prevention classification for illicit and prescription-based opioid poisoning, which specifies deaths involving opioid use as a contributory cause using the ICD-10 T-codes or as an external cause of injury using ICD-9 E-codes (Supplementary Table 2)