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Yet, most of the A PET (such as AV-45) or Tau detection fails to produce a full neurodegenerative map due to the limited penetration of the tracers across the BBB

However, TCAs are generally recommended as second-line treatments due to their higher risk of adverse effects, including orthostatic hypotension, dry mouth, constipation, urinary retention, memory impairment, hallucinations, and confusion [157]

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