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Patients currently on 2mg of Ozempic, Wegovy, or semaglutide may start at the 6mg dose of tirzepatide

On one hand, to sustain rapid proliferation, cancer cells actively reprogram iron metabolism pathways by upregulating iron import proteins such as TFR1 and DMT1, while downregulating the FPN, thereby increasing intracellular Fe + uptake, which in turn promotes mitochondrial function, DNA synthesis, and cell cycle progression ( + accumulation and lipid ROS production, inhibits the NRF2-mediated antioxidant pathway, thereby effectively activating ferroptosis in GC cells, resulting in pronounced tumor-suppressive effects ( Therefore, dysregulated iron metabolism not only drives the continuous proliferation of GC cells but also provides a potential therapeutic target