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The four-week hold per step is not arbitrary it matches the interval at which GI adverse events subside as the gut adapts

Convenience of Fewer Doses One of the biggest advantages of Semaglutide IM is that it only needs to be administered once a week

Stress and cortisol Chronic stress elevates cortisol, and high cortisol does more than make you feel on edge: It encourages fat storage, particularly around the abdomen where visceral fat accumulates

Some people maintain portions of their metabolic improvements (better insulin sensitivity, lower blood pressure) if theyve maintained weight loss through other means, but the direct medication effects disappear once semaglutide is eliminated