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The key factors that affect Rybelsus absorption are: Taking the medication on an empty stomach Using only a small amount of plain water (no more than 120 ml) Waiting the full 30 minutes before consuming anything else For patients who experience gastro-oesophageal reflux or digestive discomfort, remaining upright after taking any medication is generally advisable as a standard precaution, but this is not a specific requirement in the Rybelsus product information

Furthermore, given that glucose and lactate metabolism in mitochondria is fairly complete, these energy substrates do not contribute to the available acetylcarnitine pool

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