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Melatonin secretion related to side-effects of beta-blockers from the central nervous system
On the other hand, switching to an ADC with a different payload class has been shown to overcome resistance and increase antitumor efficacy: in patients with HER2+ metastatic breast cancer, switching from a TOPI inhibitor-based ADC to a microtubule inhibitor-based ADC or vice versa yielded significantly higher objective response rates and progression-free survival than sequencing two ADCs with the same payload class 248,249
[3] Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH
Liang Y, Li M, Yang Y, Qiao L, Xu H, Guo B
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