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Nonetheless, the TMD conformation differed and, overall, the receptor was relatively stable, exhibiting less flexibility compared with GLP-1R bound to exendin-4 or oxyntomodulin (Supplementary Fig

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Regardless of the benefits of these drugs, there have been studies that reported a link between GLP-1 receptor agonists and an increased risk of developing pancreatitis (inflammation of the pancreas), bowel obstruction, and gastroparesis (stomach paralysis)