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Description

Stabilized Nrf2 accumulates in the nucleus and activates transcription of many genes that produce antioxidant proteins

doi: 10.1074/jbc.M501489200

Plicamycin inhibits GSTM2 promoter activity and protein expression

Mitochondrial ROS are increased under hypoxia, ischemia/reperfusion injury, chemical stress, drug treatment, and under many pathophysiological conditions (Srinivasan and Avadhani, 2012)