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Safer Alternatives and Approved Treatment Pathways in the UK MHRA-authorised options for weight management include semaglutide (Wegovy, NICE TA875) and tirzepatide (Mounjaro, NICE TA1026)

Fatty liver typically progresses to cirrhosis in four stages: Fatty liver (hepatic steatosis): Excess fat in the liver Inflammation (steatohepatitis): Fat buildup causes inflammation and liver damage Fibrosis: Scarring and stiffening of the liver Cirrhosis: Severe, permanent liver damage Stages of fibrosis You may hear your doctor talk about fatty liver in terms of fibrosis stage

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Cell viability Resazurin reduction assay Resazurin (Sigma) was added to the cell culture medium (5 g/ml) for a period of at least 30 min