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The Reality of the Injection Sensation The short answer is that for the vast majority of people, the Ozempic (semaglutide) injection does not hurt significantly, and our guide on do semaglutide injections hurt goes deeper

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Around a quarter (26%) of people diagnosed with heart disease have used GLP-1 medications, and 22% of people diagnosed as being overweight or obese say they have used them or are currently using them

The most common side effects mirror those of injectable GLP-1s nausea, mild digestive discomfort, reduced appetite, and occasional headaches, particularly in the first few weeks