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( b, e, f, i, j ) The intensity of HyPerRed fluorescence of synchronized AHR or NRF2 knockout MCF-7 and U2OS cells ( b ), synchronized U2OS cells treated with Linrodostat (20 M) or Epacadostat (20 M) ( e ), synchronized IDO1 knockout or IDO1 overexpression-U2OS cells ( f ), and synchronized MCF-7 and U2OS cells transfected with si-IDO2 or si-TDO2 ( i, j ) were detected by flow cytometry for 48 h

The overexpression of SOD1 produces a large amount of H 2 O 2 that cannot be catalyzed because the copy number of catalase is normal 19

These data could partially support that implementing systematic screening for liver fibrosis in patients with diabetes could reduce the burden of liver fibrosis by MAFLD