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Molecular Cell, 2006

This is somewhat higher than the 30% rate seen with semaglutide, likely because tirzepatide activates both GIP and GLP-1 receptors, creating stronger effects on gut function

When PD-1 binds to PD-L1 or PD-L2, the intracellular domain of PD-1 becomes phosphorylated, leading to the recruitment of SHP-2 phosphatase enzymes

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