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94 Experimental and clinical research has substantiated that elevated uric acid levels exert detrimental effects on cardiovascular health, with increased oxidative stress being a key mechanism implicated in these adverse outcomes, 6,66 decreased nitric oxide availability, endothelial dysfunction, the promotion of local and systemic inflammation, vasoconstriction, vascular smooth muscle cell proliferation, insulin resistance 309 and metabolic disorder
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Expressing the dominant negative mutant H3.3Q5A in the VTA significantly reduced seeking behavior after heroin withdrawal, with behavioral tests showing over a 50% reduction in active responses, highlighting its role in reuptake susceptibility
Core regulatory network of gut microbiotametaboliteimmune axis in SLE pathogenesis The interaction between gut microbiota, their metabolites, and the host immune system constitutes a central regulatory network in the pathogenesis of SLE
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