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Using reporter genes whose activity is driven by ARE half sites or by canonical AREs consisting of two such hexamers, the authors found that cooperativity between the LBDs enables transactivation from weaker, imperfect AREs and noted that direct AREs repeats do reinforce but are not required for AR dimerization

Of those 159,000 people who took the drugs, 35 (0.04%) developed the condition compared with 19 people (0.02%) in the comparison group that didnt take the medications

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