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A single-center, quadruple-blinded randomized controlled trial evaluating the efficacy and safety of a probiotic formulation consisting of three strains of Lactiplantibacillus plantarum and Pediococcus acidilactici in symptomatic COVID-19 outpatients, showed significantly reduced viral load and lung abnormality scores and increased SARS-CoV-2 specific antibodies (Gutirrez-Castrelln et al., 2022)