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There's no strong evidence of receptor desensitization with continuous use, but periodic breaks remain standard practice in most clinical protocols

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Myelin is the fatty insulating layer that wraps around nerve axons, enabling rapid and efficient electrical signal transmission

GLP- (GLP-1) (GIP) GLP-1DPP-4GLP-1GIP GIP/GLP-1tirzepatideFDA GLP- 7 () SNAC() GIP/GLP-1tirzepatide GLP- GLP-1 2GLP-1GLP-134RCTGLP-1 HbA1c-0.55~-1.38% 1)2) GLP-1HbA1c1.0~1.5% LEADER ) 501601()9340276% 3.8() SUSTAIN- 4) 506022() PIONEER-6 5) 5060211/89615.9() REWIND 6) 5025.4() (ASCVD:)2ASCVD ASCVD SGLT2 GLP-1 LEADERSUSTAIN-6REWINDCre GLP-1 GLP-1 2-3kg GLP- GLP-110-50%GLP-1 GLP-1 GLP- GLP-1 GLP-11111 () (11) (1) (1) 31()() ()()HbA1c SGLT2DPP-4 GIP/GLP-1tirzepatide 1)Diabetes Obes Metab