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One concern with any powerful metabolic modulator is unintended consequences: for example, excessively activating AMPK might affect other pathways like muscle building or fertility

(E and F) Assessment of LY engagement of endogenously expressed target receptors in functional cell-based models: human IPS hepatocyte glucose production (GCGR) (E) and human adipocyte lipolysis assessed by glycerol production (GIPR) (F)

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