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Native IGF-1 has a circulating half-life of roughly 10 to 12 minutes when unbound

With more studies emerging, GLP-1 and dual GIP/GLP-1 medications have become well-established options for those with obesity or type 2 diabetes

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The Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results trial (LEADER) led to a paradigm shift in the wider use of GLP-1RA from promising antihyperglycemic agents to cornerstone cardiometabolic therapies, demonstrating the significant reduction of major adverse cardiovascular events (MACE) with the use of liraglutide in the population with type 2 diabetes mellitus (T2DM) [12, 13]