10.1210/endo.143.6.8873 109 OConnorD
The MPLEx protocol exemplifies this approach by enabling the simultaneous extraction of metabolites, proteins, and lipids from a single sample, which facilitates comprehensive multi-omics analysis [190]
The dual role of oxidative stress in atherosclerosis and coronary artery disease: pathological mechanisms and diagnostic potential
For example, in order to maintain intracellular redox homeostasis and build a powerful antioxidant defense, cancer cells are typically characterized by high level of antioxidants, especially GSH with a high concentration of 10 mM, which is approximately ten times higher than that in normal cells ( In general, elevated GSH can be observed in many cancers, including lung cancer, ovarian cancer, breast cancer, and head-neck cancer, and this adaptive upregulation of GSH has various effects on tumor advancement, metastasis, and drug resistance (Luis Garcia-Gimenez et al., 2013)