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Its regulation centers on four interconnected processes: iron metabolism, polyunsaturated fatty acids (PUFA) peroxidation, antioxidant defense failure, and mitochondrial dysfunction ( 2.1 Iron metabolism and ferroptosis Iron is central to ferroptosis, as its redox activity catalyzes the formation of reactive oxygen species (ROS) via Fenton reactions, triggering cellular membranes damage and cell death ( A critical regulator of intracellular iron levels is ferritinophagy, the selective autophagic degradation of ferritin mediated by nuclear receptor coactivator 4 (NCOA4)

10.1002/adhm.202101329 137 NelsonJ.ManzellaK.BakerO

Pharmacogenomics Pers

(Lausanne) 8 , 566609 (2021)