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It is, however, important to acknowledge the other side of the coin: the GLP-1 RAs are associated with rapidly increasing expenditures [15], the use of falsified drugs [16, 17], and adverse events such as gastrointestinal adverse events which may be investigated more in the future along with the increased use of the GLP-1 RAs [18, 19]

[1] [2] No, tirzepatide can be administered at any time of day without affecting its effectiveness

Slow cumulative change is almost impossible to see without reference images

The SURMOUNT trials tested specific titration speeds and found that slower escalation significantly reduced gastrointestinal side effects