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It is also notable that the labeling notes most of those affected recovered while continuing treatment
In one cohort, all 3 patients initiated on chloroquine after HCQ failure demonstrated clinical response, including one who had also failed HCQ-quinacrine combination therapy
The mitochondrial catabolic pathwayfrom BCAT-mediated transamination to BCKDH-mediated oxidative decarboxylationis depicted in Figure 1B , and the BCKDK/PPM1K regulatory phosphorylation switch governing BCKDH activity is shown in Figure 1C
It may have a lower risk of gastrointestinal side effects compared to the injectable version, though some users still report nausea and stomach discomfort
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