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In recent years, the biophysical and biochemical properties of both enzymes have been extensively studied

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64 Figure 20: GSH depletion leads to phenotypic switch A: Proliferation assay of control or BSO treated M14 melanoma cells

To ensure that the benefits of opioid analgesics outweigh the risks of addiction, abuse, and misuse, the Food and Drug Administration (FDA) has required a Risk Evaluation and Mitigation Strategy (REMS) for these products