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however, its effects on objective cognitive measures were limited

The combined effects of reduced serotonin and dopamine signaling, along with impaired GABAergic and glutamatergic regulation, create a neurobiological environment that predisposes individuals to depression (Wilson and Matschinsky 2020)

Meanwhile, understanding the reasons for carnitine unresponsiveness can refine its utilization in fertility care, allowing for adjustments in factors such as dosage, duration, or administration method to enhance effectiveness for specific patient groups

Furthermore, it may not be advantageous to ubiquitously use a potent transcriptional activator in CRISPRa as over-activation of some genes may induce unwanted effects