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B - GB: Ginkgolide B Introduction As the end stage of various Cardiovascular Ddiseases (CVDs), Heart Failure (HF) is a group of clinical syndromes caused by abnormal cardiac structural and functional changes due to various factors, leading to ventricular systolic and diastolic dysfunctions [1]

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Since an intramolecular disulfide bond forms between the N- and C-terminal CRDs (Cys310-Cys629 and Cys303-Cys598), the higher amounts of reactive oxygen species cause Yap1 to undergo transitory redox-induced conformational changes that hide the NES

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