Danons disease as a cause of hypertrophic cardiomyopathy: a systematic survey
Extracellular -synuclein oligomers function as DAMPs, activating innate immune receptors on the surface of microglia, including TLR2 (Kam et al., 2020)
Conditions associated with elevated B12 levels include: Liver disease : Hepatocellular damage releases stored B12 into circulation, with levels correlating with disease severity in conditions such as cirrhosis, hepatitis, and hepatocellular carcinoma Renal impairment : Reduced kidney function decreases B12 clearance, leading to accumulation Haematological malignancies : Myeloproliferative disorders, acute leukaemia, and polycythaemia vera can elevate B12 through increased production of B12-binding proteins (transcobalamins) Solid tumours : Certain cancers, particularly those affecting the liver or gastrointestinal tract, may elevate B12 levels A specific concern relates to cyanocobalamin in patients with Leber's hereditary optic neuropathy , a rare mitochondrial disorder
Research has focused on its role in fat metabolism, adipogenesis inhibition, and metabolic regulation
