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Wegovy contains semaglutide, a synthetic analogue of human GLP-1, a naturally occurring incretin hormone

Guests: Jennifer Wittwer, endocrinologist at The Christ Hospital Health Network Dave Knapp, founder, On the Pen Select music from Blue Dot Sessions ( www.sessions.blue )

There were no reported hospitalizations from severe hypoglycemia or ketosis

With the GLP-1 receptor there is the pathway linked to insulin control, but also a pathway that recruits the signalling molecule beta arrestin, which causes the side effects but also results in the whole receptor and drug molecule being taken inside the cell, shutting down any further activity