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This article takes no position that injection is superior for skin the evidence does not permit that position and it deliberately provides no injection instructions or human dosing recommendations

For DSIP specifically, the substitution is far more consequential, and the reason follows directly from the half-life: Subcutaneous absorption competes with a 24 minute clearance

Moreover, these associations were independent of glycemic control, potentially through the decrease in pro-inflammatory cytokines implicated in the dysregulation of hematopoiesis and the development of MPN and MDS