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Body composition changes during weight reduction with tirzepatide in the SURMOUNT-1 study
Current FDA labeling for semaglutide products includes warnings or precautions involving: Acute pancreatitis Acute gallbladder disease Acute kidney injury due to volume depletion Severe gastrointestinal reactions Hypoglycemia when combined with insulin or insulin secretagogues Diabetic retinopathy complications in susceptible patients Serious hypersensitivity reactions Pulmonary aspiration risk during general anesthesia or deep sedation Semaglutide labeling also contains a boxed warning regarding thyroid C-cell tumors observed in rodents
In fact, liraglutide (1.8 mg daily) and semaglutide (0.5 mg weekly) both significantly outperformed dulaglutide (1.5 mg weekly) for weight loss in head-to-head trials at doses that induce comparable HbA1c lowering (13, 22)
Overall, Reddy said that "while the risk of developing these conditions is low, its important for people to be aware of the possible eye side effects related to these types of medications. She advises thinking about how long you plan to take the medication
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