AEs leading to trial product discontinuation occurred in 51/603 (8.5%) participants in the CagriSema 2.4 mg/2.4 mg group, 40/605 (6.6%) participants in the semaglutide 2.4 mg group, 7/152 (4.6%) participants in the cagrilintide 2.4 mg group, 42/594 (7.1%) participants in the CagriSema 1 mg/1 mg group, 26/608 (4.3%) participants in the semaglutide 1 mg group, and 2/149 (1.3%) participants in the placebo group
Semaglutide has a much longer half-life and full dipeptidyl peptidase-4 stability compared to ligandutide, which largely lowers calorie intake
The reductions in lean mass do not necessarily indicate pathological muscle loss, as improvements in body composition, physical function, and quality of life have been reported with semaglutide and tirzepatide in subanalyses of the STEP-1 and SURMOUNT-1 programs [7,8]
However, certain insurers such as Medicare do not allow the use of these coupons