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In cancer cells, increased ROS will oxidize the specific isoform of pyruvate kinase (PKM2), diverting glucose flux towards the PPP and generation of NADPH for GSH recycling

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This mutant can still synthesize glutathione, but is not able to produce the inner membrane ABC-transporter CydDC that transports glutathione from the cytosol into the periplasm and hence suffers from reduced periplasmic glutathione levels (Mironov et al., 2020

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