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Emerging evidence indicates that distinct phosphorylation patterns, or barcodes, can influence GPCR engagement with -arrestins and determine signalling bias (9), potentially contributing to the disparity of pharmacological and therapeutic profiles observed among different GLP-1R agonists (10)

Of note, the majority of patients in this study discontinued treatment within the first trimester

Oxidative stress can induce the misfolding and oligomerization of alpha-synuclein, contributing to its accumulation and the formation of toxic aggregates [162]

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