(PubMed) Stark KD, Pawlosky RJ, Sokol RJ, Hannigan JH, Salem N, Jr
The loss of insulin sensitivity of hippocampal CA1 pyramidal neurons can subsequently cause long-term Ca 2+ -dependent afterhyperpolarizations (AHPs), which can produce significant cognitive and memory impairment in the short term and throughout life, contributing to depression (122, 123)
During the perimenopausal and postmenopausal periods, declining oestrogen levels are associated with increased central adiposity, insulin resistance, and a higher risk of metabolic syndrome
People with complex medical histories Users with complex medication regimens, relevant comorbidities, or conditions that require careful monitoring alongside semaglutide use should seek out providers who offer more comprehensive clinical oversight