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But these chemicals are used in very, very high concentrations for cell reprogramming. Sinclair declined to describe the exact makeup of the drug candidate, code-named SL-100, calling its contents highly, highly confidential. However, he has previously published lab studies of what he called epigenetic age-reversal cocktails, which mixed powerful chemicals with known supplements and commercially available medicines

Overexpression of these mi-RNAs increased ECM degradation, the inflammatory response, and MMP-13 expression in chondrocytes